This is a newsletter from NextBioForm, a center coordinated by RISE with the goal to deliver better formulations for biopharmaceuticals. From the long-term perspective, our goal is to create stable biopharmaceuticals that will improve the quality of life for patients.
Read past NextBioForm newsletters and subscribe here |
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| We are approaching spring and nd we are looking forward to brighter times. Within NextBioForm, we have an exciting spring ahead of us with several dissertations and publications. |
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| In December 2023, Johan Engblom was elected to become member of the NextBioForm board. We have talked to Johan about his work as Professor and Prefect for the Department of Biomedical Science at Malmö University (MaU), his views on centers like NextBioForm and much more. |
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| On 2nd of February 2024, Shuai Bai successfully defended his licentiate thesis titled " Enhancing the Stability of Probiotics: Freeze-drying and Encapsulation" at Lund University, Division of Food and Pharma. We asked him some questions about his research. |
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The humidity in the environment affects drugs during processing as well as during storage. To be able to study the real-world effect of humidity on drugs, our postdoctoral researcher within WP4 has worked on designing and prototyping a suitable humidity environment for CoSAXS.
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This article investigates how vacuum foam-drying of a bioactive protein is influenced by different formulation parameters by scrutinizing the foam structure, physical properties of the foam (protein surface coverage and matrix stability), and the activity of the protein. Formulation parameters differed on matrix formers and the presence of different surface-active competitors. The results showed that the activity of the protein was preserved after vacuum foam-drying and rehydration. Moreover, the thickness of the dry, solid foam was estimated to be 20–50 µm. Interestingly, the choice of matrix former, and to some extent the presence of a surface-active competitor, greatly impacted the foam formation, the protein surface coverage, and the matrix stability.
Authors: Daniel Tristan Osanlóo, Denny Mahlin, Simon Bjerregaard, Björn Bergenståhl, Anna Millqvist-Fureby
Link to the publication → |
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