This is a newsletter from NextBioForm, a center coordinated by RISE with the goal to deliver better formulations for biopharmaceuticals. From the long-term perspective, our goal is to create stable biopharmaceuticals that will improve the quality of life for patients.
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| This spring has seen us coming back to the offices and to meeting in person. This has boosted the energy of us all and activities in NextBioForm are vibrant. We have seen several publications and halftime seminars among our young researchers. Read about our first PhD graduate Ekaterina Bogdanova below. |
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"NextBioForm is a knowledge center that combines Academia and Industry professionals" |
"I feel really lucky, that I got PhD position in NextBioForm in 2018. I became a part of an international team of researchers in Sweden Tuan Phan-Xuan, Anna Fureby, Vitaly Kocherbitov, and Ann Terry. We traveled a lot around Europe at synchrotron facilities doing X-ray scattering experiments before MAX IV started operation. I gained a lot of experience in sample preparation/synchrotron beamline operations. Also I learned a lot about doing research on site, away from the 'house lab'."
Read the full interview
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| Defending PhD student Ekaterina with her supervisors. From the left, Prof. Vitaly Kocherbitov, NextBioForm centrum director Dr. Anna Fureby, Dr. Ekaterina Bogdanova and Dr. Tuan Phan-Xuan. |
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Authors: Johanna Hjalte*, Shakhawath Hossain, Andreas Hugerth, Helen Sjögren, Marie Wahlgren, Per Larsson and Dan Lundberg
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Understanding aggregation behaviour of peptides is important in the development of a pharmaceutical product, as it can impact whether the molecule is suitable to develop into a product, and what kind of formulation strategy that could be applied. To investigate the ability of 1H NMR and all atom molecular dynamics simulations (AA-MD) to identify differences in aggregation behaviour, a series of 4 structurally related pharmaceutic peptides were selected. Of the four, one was expected to not aggregate at all and three are expected to form fibrils. Both methods showed the non-aggregating behaviour in line with expectation, while also differentiating the aggregation behaviour of the other three. 1H NMR gave further insight into coexisting aggregate structures as well as to whether the counterion was involved in the aggregates formed, while AA-MD provided further information on aggregation pathways and residues involved in peptide-peptide interactions.
Read the publication here
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Authors: Lingping Zhang, Marie Wahlgren and Björn Bergenståhl
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The key for an oil-based control release system that targeted the later part of the gastrointestinal tract is to control/retard the lipolysis before the formulation reaches the target location. The human body has evolved the lipolysis in a way that almost all the nature lipids consumed could be digested. Therefore, it is not easy to stop or even just slow down. In this paper, we first established an in vitro system that, as close as possible, mimics the complex digestion environment. Then, by using this system we were trying to compare different mechanisms of retardation. This gave us an overview of general rules for retardation of lipolysis. It also showed that creating a gel based on ethyl cellulose and the oil gave the best retardation.
Read the publication here
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