This is a newsletter from NextBioForm, a center coordinated by RISE with the goal to deliver better formulations for biopharmaceuticals. From the long-term perspective, our goal is to create stable biopharmaceuticals that will improve the quality of life for patients.
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As NextBioForm begins its sixth year, we anticipate a very exciting year. The PhD students at the center are currently in a stage when they are releasing a number of interesting studies on various facets of biologics formulation. You can read more about the publications we've already seen this year in this newsletter.
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Anna Fureby has received a professorship at LTH and will start her position there on the first of April, at the same time as Randi Nordström returns from her parental leave.
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On an early Thursday morning in February, eight people from NextBioForm meet up in the MAXIV reception. After receiving their access cards and dosimeter they stepped into the experimental hall. They were there to participate in a hands-on educational beamtime.
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SARomics Biostructures is a company that was founded in 2006 in Lund, which helps pharmaceutical and biotech companies to determine the structure of proteins. "NextBioForm and the research which is done within the project is important since physical chemistry can better understand why proteins behave as they do in different formulation and what the different molecular driving forces are", says Carl Diehl who works as a Senior Scientist and Manager NMR Services at SARomics Biostructures.
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NextBioForm, together with SweDeliver, organizes the conference "New Horizon on drug delivery and formulation" on November 27-29 2023 at Uppsala Konsert & Kongress in Uppsala.
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Along with the Swedish Research Council, Vinnova held the biological medicine program's closing conference on March 21.
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Authors: Linnea Gustafsson, Mathias Kvick, Carolina Åstrand, Nienke Ponsteen, Nicolai Dorka,Veronika Hegrová, Sara Svanberg, Josef Horák, Ronnie Jansson, My Hedhammar, and Wouter van der Wijngaart. |
The structure of a freeze-dried material is essential for its ability to preserve and protect biologics such as probiotics. The objective is to evaluate X-ray microtomography as a quantification method to study freeze dried structure (dried with different protocols). The image analysis has been focused on understanding the thickness of the encapsulating structures. The common structures observed are pores of around 20-100 µm separated by thin walls around 2-3 µm thick. The structures display comparably small differences between the different drying protocols despite the quite different drying conditions.
Read the publication here
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Authors: Zandra Gidlöf, Betty Lomstein Pedersen, Lars Nilsson, Anita Teleman, Marie Wahlgren, Anna Millqvist-Fureby. |
Starch microspheres is interesting for numerous applications, one of them being controlled delivery. The microspheres can be prepared via crystallisation in aqueous two-phase systems (ATPS) composed of water, starch, and polyethylene glycol (PEG). However, both starch crystallisation and ATPS phase behaviour are complex phenomena, and fundamental understanding is limited.
In this work, we investigated starch-PEG ATPS phase behaviour in relation to microsphere formation and microsphere properties. By mapping a starch-PEG ATPS phase diagram and comparing microsphere preparation at different positions, we found a production space where phase behaviour can influence the rate of microsphere formation and particle size, while still obtaining similar additional properties in the finished product.
Read the publication here
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Authors: Shuai Bai Palmkron, Björn Bergenståhl, Sebastian Håkansson, Marie Wahlgren, Anna Millqvist Fureby, Emanuel Larsson. |
The structure of a freeze-dried material is essential for its ability to preserve and protect biologics such as probiotics. The objective is to evaluate X-ray microtomography as a quantification method to study freeze dried structure (dried with different protocols). The image analysis has been focused on understanding the thickness of the encapsulating structures. The common structures observed are pores of around 20-100 µm separated by thin walls around 2-3 µm thick. The structures display comparably small differences between the different drying protocols despite the quite different drying conditions.
Read the publication here
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